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Given early in attack, reliefis often dramatic and lower doses suffice, butwhen pain has become severe—larger doses areneeded and control may be achieved only afterfew hours

Given early in attack, reliefis often dramatic and lower doses suffice, butwhen pain has become severe—larger doses areneeded and control may be achieved only afterfew hours. The response isslow (takes 2–6 months) and incomplete, but upto60% subjects derive some benefit, albeit for shortperiods

The response isslow (takes 2–6 months) and incomplete, but upto60% subjects derive some benefit, albeit for shortperiods.

In 2013 therewas a steady increase in reported usage of any illicit drug with increasing age:20% of 8th graders, 38% of 10th graders, and 50% of 12th graders.

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